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Ibotenic acid or (S)-2-amino-2-(3-hydroxyisoxazol-5-yl)acetic acid, also referred to as ibotenate, is a chemical compound and psychoactive drug which happens naturally in Amanita muscaria and associated species of mushrooms sometimes found in the temperate and boreal areas of the northern hemisphere. It is a prodrug of muscimol, broken down by the liver to that rather more stable compound.[2] It's a conformationally-restricted analogue of the neurotransmitter glutamate, and resulting from its structural similarity to this neurotransmitter, acts as a non-selective glutamate receptor agonist.[3] Because of this, ibotenic acid might be a strong neurotoxin in excessive doses, and is employed as a "mind-lesioning agent" via cranial injections in scientific research.[4][5] The neurotoxic results look like dose-associated and risks are unclear by means of consumption of ibotenic-acid containing fungi, although thought how to use a weber charcoal grill be negligible in small doses.[6][higher supply needed]

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